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Benefits & Risks

As with the consumption of any psychedelic, there are inherent psychological and physiological risks involved with taking 5-MeO-DMT. Those who are prescribed and are actively taking MAOIs (monoamine oxidase inhibitors) or certain anti-depressants should not consume 5-MeO-DMT due to the possible, albeit rare risk of Serotonin Syndrome which can be fatal.

Due to the possibility of fluctuations in heart rate, the use of 5-MeO-DMT by those with heart conditions could prove dangerous and is discouraged.

The breakthrough experience with the drug is extraordinarily powerful and as with other psychedelics at high doses, there is a possibility for emotional or psychological distress during or after a trip.

Nausea is also a common side effect during the onset of the experience but tends to subside quickly and there is a possibility users may dissociate or interact inappropriately with their environments.

Many risks associated with the drug can be minimized by following the steps in our user guide and ensuring you prepare for your trip safely.

While there is limited research into the therapeutic use of 5-MeO-DMT, most people report profound, often life changing mystical experiences and a sense of oneness with the universe. When integrated properly, these types of experiences are often associated with a greater sense of empathy, a deeper connection with our communities and a heightened sense of satisfaction and overall wellbeing in day-to-day life.

In the early studies that have been conducted, study participants who reported being diagnosed with psychiatric disorders including post-traumatic stress disorder, depression, anxiety and substance abuse disorders claimed improvements to their symptoms following their 5-MeO-DMT sessions.

A 2018 study from Brazil demonstrated a single 5-MeO-DMT dose stimulated the proliferation of nerve cells in the hippocampus of mice. This type of neurogenic and neuroplasticity promoting effect is thought to contribute to the antidepressant properties of serotonergic psychedelics similar to 5-MeO-DMT.


While research into the drug’s effects is in its nascent stage, the preliminary clinical findings and anecdotal evidence show promise for mental health and addictions support and treatment applications.

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